Epidemiology and burden of systemic lupus erythematosus in a. Prior to the 1985 conference on prognosis studies, the partici pants were asked to. Pdf aims the systemic lupus international collaborating clinics slicc have recently suggested a new set of criteria for the classification of sle find. Gladman was a key facilitator in the development and validation of the sliccacr damage index. The slicc criteria were validated by analysis of 690. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and is especially prevalent among women of. Apr 27, 2016 using the slicc criteria, patients with scle sle were more likely to have low complement.
Objectives several populationbased studies on systemic lupus erythematosus sle have been reported, yet communitybased, individualcase validated, comprehensive. This systemic lupus diagnostic criteria slicc calculator helps the classification and diagnosis of sle based on clinical and immunological criteria. Prior to the 1985 conference on prognosis studies, the partici pants were asked to assess the importance of individual items that might be included in a damage index 7. Slicc, systemic lupus international collaborating clinicsamerican college of rheumatology damage index. Systemic lupus erythematosus sle is a prototypic autoimmune disease, affecting more than 300,000 in the united states and millions worldwide. What are eularacr diagnostic criteria for systemic lupus. Malar rash fixed erythema, flat or raised, over the malar eminences, tending to spare the nasolabial folds 2. Slicc damage index score in systemic lupus erythematosus. Accuracy of systemic lupus international collaborating clinics. A list of items that should be included in a damage index, with. Sle is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. The recent used diagnostic criteria widely used for sle is 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems.
Thus, slicc 12 criteria were applied to confirmed sle cases in our regional sle register as well as to individuals. Epidemiology and burden of systemic lupus erythematosus in. Sle is an autoimmune disease in which the immune system attacks its own tissues, causing widespread. Slicc classification criteria for sle current medical. American college of rheumatology classification criteria for. Pdf 2015 acrslicc revised criteria for diagnosis of. Patients with ile met three acr criteria and were not classified with sle by slicc standards. The systemic lupus international collaborating clinics slicc recently validated an alternative system. In september 2019, the european league against rheumatism eular and the american college of rheumatology acr published new criteria for the classification of. Altmetric use of slicc criteria in a large, diverse lupus. To assess the limitations of the slicc systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus sle, in patients with primary.
Comparison between three systems of classification criteria in juvenile systemic lupus erythematous adriana r. Sleacronly were classified with sle by acr criteria, but not slicc criteria. However, our patient met the acr criteria for sle which has a sensitivity of 85% and specificity of 95%11 as he had arthralgias, pleural and pericardial effusions, lymphopenia and raised anti. Pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor. They met the criteria for sle primarily on their cutaneous signs and positive serology. Pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Table lists the sensitivity and specificity of each criterion in slicc sle criteria. These criteria are useful and give consistency in the classification. Thus, slicc 12 criteria were applied to confirmed sle cases in our regional sle register as well as to individuals with a fair suspicion of systemic autoimmune. Other criteria were chosen from 7 clinical constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal and 3 immunologic antiphospholipid antibodies, complement proteins, sle specific antibodies categories, and weighted from 2 to 10. Systemic lupus diagnostic criteria slicc calculator. Systemic lupus erythematosus sle, is the most common type of lupus. Positive ana or positive antidsdna revised 2015 criteria endorsed by the acr combines 1997 criteria and slicc criteria 4 out of 16 points, definite sle 3 out of 16 points.
In addition to the features noted in the slicc criteria, patients with sle frequently experience. Apr 11, 2020 in september 2019, the european league against rheumatism eular and the american college of rheumatology acr published new criteria for the classification of sle. Use of slicc criteria in a large, diverse lupus registry. Discoid rash erythematous raised patches with adherent keratotic scaling and follicular. The present study is the first to evaluate the performance of slicc12 in an adult european study population. In this initial validation testing, the slicc revised criteria had greater sensitivity but.
In the text below the form there is information on the slicc, along with instructions on how to interpret the criteria that is present. Slicc criteria for sle slicc classification criteria for. A statistically insignificant increase was seen in individuals meeting the slic. To develop new classification criteria for systemic lupus erythematosus sle jointly supported by the european league against rheumatism eular and the american college of rheumatology acr. Cases were ascertained by the acr 1997, slicc 2012. A statistically insignificant increase was seen in individuals meeting the slic criteria. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology. Slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore.
Systemic lupus erythematosus sle is an autoimmune disease that can involve any organ system, exhibiting great diversity in presentation. Overlap syndrome involving systemic lupus erythematosus. Although the acr and slicc criteria can be helpful as they have a high sensitivity for systemic lupus, their use needs to be paired with the clinical context and patient evolution. Systemic lupus erythematosus sle is a multisystem autoimmune disease with diverse and varied clinical manifestations and longterm outcomes. To ensure that there is a consistent definition of sle for the purposes of research and surveillance, classification criteria for sle are needed. Objectives several populationbased studies on systemic lupus erythematosus sle have been reported, yet communitybased, individualcase validated, comprehensive reports are missing. Pdf 2015 acrslicc revised criteria for diagnosis of systemic. Although both men and women of all age groups can be affected, women outnumber men.
To date there are no specific classification criteria for childhoodonset systemic lupus erythematosus csle. Systemic lupus erythematosus is a multiorgan system autoimmune disease with clinical and serological heterogeneity. New 2019 sle eularacr classification criteria are valid. Sleslicconly were classified with sle by slicc criteria, but not acr criteria. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and.
Fulfillment of at least 4 criteria at least one clinical criterion and at least one immunologic criterion or lupus nephritis as the sole clinical criterion in the presence of ana or antidsdna antibodies petri m et al arthritis rheum 2012. The present study is the first to evaluate the performance of slicc 12 in an adult european study population. Classification of primary antiphospholipid syndrome as. Both the acr revised criteria and the validated slicc criteria are designed for classification of patients for clinical studies and have not been tested for purposes of. Altmetric use of slicc criteria in a large, diverse. The formulation of initial criteria for sle was first proposed by the. Gladman was a key facilitator in the development and validation of the slicc acr damage index. Sle is a chronic disease of variable severity with a waxing and waning course, with signifi cant morbidity that can be fatalif not treated earlyin some patients fi gure 1. The slicc criteria are more consistent with advancing concepts of sle, and they will exert substantial impact on clinical practice.
The formulation of initial criteria for sle was first proposed by the american college of rheumatology and appeared in 1971. Performance of the new slicc classification criteria in juvenile systemic lupus erythematosus, in two observation periods. The use of slicc and acr criteria to correctly label patients. Comparing the acr and the slicc criteria for the classification of sle patients using data from an existing multiethnic cohort. Sle classification using slicc criteria requires either meeting. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and. Sle is a multisystem autoimmune disease with a wide spectrum of clinical patterns that affects all ages and ethnicities. The recent used diagnostic criteria widely used for sle is 2015 acrslicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. Application of the 2012 systemic lupus international. Systemic lupus erythematosus sle is a chronic autoimmune disease characterised by multisystem manifestations. Oct 22, 2015 pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore.
The systemic lupus international collaborating clinics slicc. The 2012 revised slicc criteria for classification of. Sliccacr criteria dont id severe internal disease in scle. Comparison between three systems of classification criteria. The systemic lupus erythematosus international collaborating clinics slicc group has recently proposed a revised classification criteria, 10 which hopes to replace the 1997 american college of rheumatology criteria, 11 to improve on the sensitivity and specificity table 1.
Slicc damage index score in systemic lupus erythematosus pat. Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat. Comparing the acr and the slicc criteria for the classification of. The slicc criteria were validated by analysis of 690 patients with sle or other rheumatic diseases. As the precursor of the slicc group, members of the nato conference on prognosis studies in sle which took place in 1985 in toronto, recognized the need for three instruments to better describe the prognosis of sle including the domains of disease activity, accumulated damage.
Objective sle is traditionally classified using the american college of rheumatology acr criteria. Comparison between three systems of classification. However, our patient met the acr criteria for sle which has a sensitivity of 85% and specificity of 95%11 as he had arthralgias, pleural and pericardial effusions, lymphopenia and raised antidsdna, and met 5 out of 11 criteria according to newer systemic lupus international collaboration clinics criteria slicc criteria due to decreased. Derivation and validation of systemic lupus international. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often. Sleboth were classified with sle by both slicc and acr criteria. C3 and c4 can be measured readily, and are now part of the slicc classification criteria for sle. Comparison among acr1997, slicc and the new eularacr. The new 2019 sle european league against rheumatismamerican college of rheumatology eularacr classification criteria for systemic lupus erythematosus sle. Sle is on the other hand a seminal syndrome that has. Pathology outlines systemic lupus erythematosus sle ultrasonography and ct guided percutaneous renal biopsy in.
Slicc criteria for sle slicc classification criteria for sle. The use of slicc and acr criteria to correctly label. Erythematosus nih public access collaborating clinics. Using the slicc criteria, patients with sclesle were more likely to have low complement. Pdf g358 the performance of the new slicc criteria for the. In 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc 12 to classify systemic lupus erythematosus sle. Fulfillment of at least 4 criteria at least one clinical criterion and at least one immunologic criterion or lupus nephritis as. The systemic lupus collaborating clinics slicc revised the acr sle classification criteria and validated new criteria in order to improve.
Cardiac tamponade as the initial presentation of systemic. Jun 16, 2016 systemic lupus erythematosus sle is an autoimmune disease that impacts many body systems, with a wide variety of signs and symptoms in each patient. The manhattan lupus surveillance program mlsp is a population. Association of iga anti2 glycoprotein i with clinical and. Th e figure 1 natural history of systemic lupus erythematosus. The new 2019 eularacr classification criteria for sle requires a positive ana as obligatory entry criterion. Systemic lupus erythematosus is a systemic autoimmune disease with a worldwide distribution. In 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc12 to classify systemic lupus erythematosus sle. Use of slicc criteria in a large, diverse lupus registry enables sle. Clinics slicc 2012 criteria were more sensitive than the american college of rheumatology acr 1997 criteria in reallife systemic lupus erythematosus sle clinical practice. Racgp systemic lupus erythmatosus when to consider and.
Systemic lupus erythematosus sle is an inadequately defined syndrome. The diagnosis of sle and ra was based on the 2015 systemic lupus international collaborating clinics slicc and american college of. As the precursor of the slicc group, members of the nato. Classification criteria for systemic lupus erythematosus.
Validation of the systemic lupus international collaborating clinics. This study aims to compare the performance among the american college of rheumatology acr 1997, the systemic lupus international collaborating clinics criteria slicc and the new european league against rheumatism eularacr criteria, in a csle cohort. Accaha cv risk calculator 20 estimate 10year risk for atherosclerotic cardiovascular disease revised cardiac risk index lee criteria rapid preop assessment using the revised cardiac risk index asymptomatic ica internal carotid artery stenosis surgical risk stratification gupta perioperative cardiac risk determine perioperative risk for a wide array of surgeries. Diagnostic criteria for systemic lupus erythematosus. Other criteria were chosen from 7 clinical constitutional. It is important to screen patients with cle routinely for sle.
Our patient met 4 criteria of the slicc criteria for sle proposed in 2012 by the systemic lupus collaborating clinics, including acute cutaneous lupus erythematosus. Jul 14, 2014 both the acr revised criteria and the validated slicc criteria are designed for classification of patients for clinical studies and have not been tested for purposes of diagnosis. Derivation and validation of the systemic lupus international. Accaha cv risk calculator 20 estimate 10year risk for atherosclerotic cardiovascular disease revised cardiac risk index lee criteria rapid preop assessment using the revised. The 2012 systemic lupus international collaborating clin ics slicc classification criteria addressed many of these issues. Feb 08, 2016 systemic lupus erythematosus, sle, sle nephritis, sle management, sle classification, acr vs slicc criteria, new drugs in sle. In the derivation set, the slicc classification criteria resulted in fewer. Both the acr revised criteria and the validated slicc criteria are designed for classification of patients for clinical studies and have not been tested for purposes of diagnosis. The slicc criteria for sle classification requires. Systemic lupus erythematosus, sle, sle nephritis, sle management, sle classification, acr vs slicc criteria, new drugs in sle. We studied the sle epidemiology and burden on the island of crete during 199920. In the past few decades, there is a significant improvement in the management and survival rates, however the morbidity due to organ damage remains unresolved. New eularacr classification criteria for sle rheumnow.